A lizardlike reptile of the genus Chamæleo, of several species, found in Africa, Asia, and Europe. The skin is covered with fine granulations; the tail is prehensile, and the body is much compressed laterally, giving it a high back.
- Any of various tropical Old World lizards of the family Chamaeleonidae, characterized by their ability to change color.
- See anole.
- A changeable or inconstant person: "In his testimony, the nominee came off as . . . a chameleon of legal philosophy” ( Joseph A. Califano, Jr.)