To deprive of nerve, force, strength, or courage; to render feeble or impotent; to make effeminate; to impair the moral powers of.
- To weaken or destroy the strength or vitality of: "the luxury which enervates and destroys nations” ( Henry David Thoreau). See Synonyms at deplete.
- Medicine To remove a nerve or part of a nerve.
- Deprived of strength; debilitated.