To treat, work, or operate with the hands, especially when knowledge and dexterity are required; to manage in hand work; to handle; as, to manipulate scientific apparatus.
- To move, arrange, operate, or control by the hands or by mechanical means, especially in a skillful manner: She manipulated the lights to get just the effect she wanted.
- To influence or manage shrewdly or deviously: He manipulated public opinion in his favor.
- To tamper with or falsify for personal gain: tried to manipulate stock prices.
- Medicine To handle and move in an examination or for therapeutic purposes: manipulate a joint; manipulate the position of a fetus during delivery.